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Jeffrey A Brinker, M.D.

Jeffrey A Brinker, M.D.

  • Professor of Medicine
  • Joint Appointment in Radiology and Radiological Science

https://www.hopkinsmedicine.org/profiles/results/directory/profile/0001297/jeffrey-brinker

The period of maximum communicability is considered to be several days before and after parotitis 1 Centers for Disease Control and Prevention order levitra with dapoxetine canada erectile dysfunction herbal remedies. The recommended isolation period for mumps is 5 days after onset of parotid swelling discount 40/60 mg levitra with dapoxetine visa impotence reasons. Virus has been isolated from saliva from 7 days before through 8 days after onset of swelling discount 40/60mg levitra with dapoxetine mastercard erectile dysfunction 38 years old. The incubation period usually is 16 to 18 days, but cases may occur from 12 to 25 days after exposure. People with parotitis without other apparent cause should undergo diagnostic testing to confrm mumps virus as the cause or to diagnose other etiologies (eg, infuenza A virus, parainfuenza viruses 1 and 3, and bacterial causes. Confrming the diagnosis of mumps in highly immunized populations is challenging, because the IgM response may be absent or short lived; acute IgG titers already might be high, so no signifcant increase can be detected between acute and convalescent speci mens; and mumps virus might be present in clinical specimens only during the frst few days after illness onset. Emphasis should be placed on obtaining clinical specimens within 1 to 3 days after onset of symptoms (usually parotitis. When determining means to control outbreaks, exclusion of students without evidence of immunity who refuse immunization from affected schools and schools judged by local public health authorities to be at risk of transmission should be considered. Students who continue to be exempted from mumps immunization because of medical, religious, or other reasons should be excluded until at least 26 days after onset of parotitis in the last person with mumps in the affected school. Mumps vaccine has not been demonstrated to be effec tive in preventing infection after exposure. A second dose may be considered for preschool-aged children and other adults depending on outbreak epidemi ology. Postlicensure data indicate that the effectiveness of 1 dose of mumps vaccine has been approximately 80% (range, 62%–91%), and on the basis of fewer studies globally, 2-dose vaccine effectiveness has been somewhat higher (range, 79%–95%. Some studies and investigations conducted during the mumps outbreaks in the late 1980s and in 2006 indicate that vaccine-induced immunity might wane, possibly explaining the recent occur rence of mumps in the 15 through 24-year age group. Adequate immunization is 2 doses of mumps-containing vaccine for school-aged children and adults at high risk (ie, health care personnel, students at post-high school educational institutions, and international travelers), and a single dose of mumps-containing vaccine for other adults born in or after 1957. Orchitis, parotitis, and low-grade fever have been reported rarely after immunization. Temporally related reactions, includ ing febrile seizures, nerve deafness, aseptic meningitis, encephalitis, rash, pruritus, and purpura, may follow immunization rarely; however, causality has not been established. Allergic reactions also are rare (see Measles, Precautions and Contraindications [p 497], and Rubella, Precautions and Contraindications [p 634]. Children with minor illnesses with or without fever, such as upper respiratory tract infections, may be immunized (see Vaccine Safety, p 41. However, if other manifestations suggest a more seri ous illness, the child should not be immunized until recovered. Hypersensitivity reactions occur rarely and usually are minor, consisting of wheal and fare reactions or urticaria at the injection site. Reactions have been attrib uted to trace amounts of neomycin or gelatin or some other component in the vaccine formulation. People with allergies to chickens or feathers are not at increased risk of reaction to the vaccine. People who have experienced anaphylactic reactions to gelatin or topically or systemically administered neomycin should receive mumps vaccine only in settings where such reactions could be managed and after consultation with an allergist or immu nologist. Most often, however, neomycin allergy manifests as contact dermatitis, which is not a contraindication to receiving mumps vaccine (see Table 1. The risk of mumps exposure for patients with altered immunity can be decreased by immunizing their close susceptible (ie, house hold) contacts. This interval is based on the assumptions that immunologic responsive ness will have been restored in 3 months and the underlying disease for which immu nosuppressive therapy was given is in remission or under control. For patients who have received high doses of corticosteroids (2 mg/kg/day or greater or greater than 20 mg/day of prednisone or equivalent) for 14 days or more and who otherwise are not immunocompromised, the rec ommended interval is at least 1 month after corticosteroids are discontinued (see Immunocompromised Children, p 74. Conception should be avoided for 28 days after mumps immunization because of the theoretical risk associated with live-virus vaccine. Susceptible postpubertal females should not be immunized if they are known to be pregnant. Mumps immuni zation during pregnancy has not been associated with congenital malformations (see Measles, p 489, and Rubella, p 629. Bullous myringitis, once considered pathog nomonic for mycoplasma, now is known to occur with other pathogens as well. Symptoms are variable and include cough, malaise, fever, and occasionally, headache. Acute bronchitis and upper respiratory tract illness caused by M pneumoniae generally are mild and self-limited. Approximately 10% of infected school-aged children will develop pneumonia with cough and widespread rales on physi cal examination within days after onset of constitutional symptoms. Bilateral diffuse infltrates or focal abnormalities, such as consolida tion, effusion, or hilar adenopathy can occur. Unusual manifestations include nervous system disease (eg, aseptic meningitis, encephalitis, acute disseminated encephalomyelitis, cerebellar ataxia, transverse myelitis, peripheral neuropathy) as well as myocarditis, pericarditis, polymorphous mucocutaneous eruptions (including classic and atypical Stevens-Johnson syndrome), hemolytic anemia, and arthritis. In patients with sickle cell disease, Down syndrome, immunodefcien cies, and chronic cardiorespiratory disease, severe pneumonia with pleural effusion may develop. Acute chest syndrome and pneumonia have been associated with M pneumoniae in patients with sickle cell disease. Several other Mycoplasma species colonize mucosal surfaces of humans and can produce disease in children.

Syndromes

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Examination of tongue morphology and a careful assessment for lymph-adenopathy are also important purchase 40/60mg levitra with dapoxetine with amex injections for erectile dysfunction cost. The examination of the tongue is divided into two parts: examination of the tongue body; and examination of the tongue coat levitra with dapoxetine 40/60 mg mastercard erectile dysfunction young age treatment, which is also sometimes called the moss purchase generic levitra with dapoxetine erectile dysfunction test. Examination of the tongue body yields information on the general nutritive and structural condition of the internal organs and their tissues. It also provides information on the condition of the blood and the bloodstream, which infuses and supplies the internal organs with the nutrients and vital principles they need. Examination of the tongue coat yields information on imbalances prevailing in the body, particularly in the digestive tract. Generally, the tongue body portrays conditions that are more deep seated, systemic or chronic, whereas the tongue coat portrays conditions that are more acute, transient or superficial. Tongue body texture, its shape, size, colour, moisture, coating, nature of papillae and the movements are the important components of the tongue examination. Tongue Body Texture Look for the general texture of the tongue body is it smooth or rough, rumpled or flat. In Greek medicine, the general texture of the tongue body indicates deep-seated, systemic conditions of dryness or wetness prevailing in the organism. Basically, roughness or dryness indicates a Dry temperament, whereas smoothness and wetness indicate a Wet temperament. If the tongue is also swollen or enlarged, this indicates that the body is retaining excess fluids, that body fluid metabolism has become sluggish or obstructed, and fluid excretion deficient. A dry tongue, especially when accompanied by severe thirst, indicates a condition of dryness in the organism. A rumpled tongue, dimpled with numerous rises, dips, and depressions like a rocky road filled with potholes, generally indicates a sluggish, inefficient digestion and digestive enzymes. Such a tongue will often have a thick, greasy coat, indicating the presence of toxins due to deficient or defective digestive enzymes. A rough, grainy tongue surface generally indicates a Dry temperament, and can show a constitutional deficiency of the Radical Moisture and the moist, flourishing Phlegmatic and Sanguine humors. Such tongue conditions are usually inherited or congenital, and are not acute, serious or critical. A raw tongue, that looks like a slab of raw meat, and is dark red in color, is generally a sign of advanced consumption, deficiency heat, and a severe depletion of the vital fluids. Most cracks are located on the midline of the tongue, which represents the spinal column. Size A normal, healthy tongue should be sufficiently fleshy and robust, and neither too fat nor too thin. A good feel and understanding for what exactly constitutes normal tongue size comes mainly from the accumulation of clinical experience and observing many different tongues. Basically, diseases or conditions of repletion or excess will present with an enlarged or swollen tongue; the greater the swelling or enlargement, the greater the excess. Conversely, a thin, emaciated tongue indicates a disease or condition of depletion, or deficiency, and a generalized malnourishment of the organs and tissues. One telltale sign of an enlarged, swollen tongue is the presence of an irregular shape, with rounded half-circle indentations around the edges called scalloped edges. This is caused by the enlarged tongue pressing against the inside edges of the teeth. Color the overall color of the body of tongue shows the general condition of the blood and the bloodstream, and basic balance of humors and nutrients. A discoloration of the tongue body localized in a particular reflex zone of the tongue indicates an imbalance occurring in its corresponding organ. The normal color of a healthy tongue is a nice, robust, sanguine pink a perfectly balanced blend of red and white. Any deviation from this denotes a deviation from this ideal state of health and balance; the greater the deviation, the more severe the imbalance. White, Pale: Generally indicates coldness and deficiency, as well as an excess of cold phlegmatic humors in the bloodstream. This may also indicate anaemia or blood deficiency, if supported by other signs and symptoms. Red: Generally indicates an excess of heat in the body systemic if the whole tongue body is affected, or localized in a particular organ or part if only certain reflex zones are affected. A dark red tongue is often a sign of chronic consumptive or deficiency heat, or a consumptive fever or dyscrasia of the blood. Purple: Indicates either blood stagnation or cyanosis due to a deficiency of vital principles Vital Force and/or Innate Heat in the blood. Reddish purple tongue indicates stagnation of the blood and a light purple tongue indicates stagnation of the Vital Force. Purple spots on the tongue indicate a severe stagnation or cancellation of blood in the corresponding organ. Lighter or subtler shades of purple indicate a stagnation of the Vital Force that guides the blood; darker shades of purple indicate a stagnation of the blood itself. Yellow: Generally indicates jaundice, or an excess of bilious, choleric residues backed up into the blood. Brown: Indicates an excess of black bile or melancholic residues in the bloodstream. Other characteristics a) Central cyanosis bluish discoloration a) Jaundice Yellowish discoloration b) Advanced uremia Brown colour c) Ketosis Brown discoloration d) Ribifralvin deficiency Meganta colour e) Niacin and some other B complex deficiency Bright scarlet or beefy red tongue f) Severe anaemia pallour 4.

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You dont want the knowledge that comes from ordinary think ing and reasoning: Let go of it cheap 40/60 mg levitra with dapoxetine otc impotence trials. You dont want the knowledge that comes from directed thought and evaluation: Stop buy levitra with dapoxetine 40/60mg low cost impotence 36. All the con cepts youve known — dealing with the world or the Dhamma generic levitra with dapoxetine 40/60mg with amex how is erectile dysfunction causes, however many or few — are washed away. In other words, you dont have to be afraid of being stupid or of missing out on things. You dont want any of the insights youve gained from listening to others or from reading books, because theyre concepts, and so theyre inconstant. You dont want any of the insights youve gained by reasoning and thinking, because theyre concepts, and so theyre not-self. Let all these insights disappear, leaving just the mind, frmly intent, leaning neither to the left — towards being displeased; nor to the right — towards being pleased. When you can catch sight of the shadow appearing, thats vipassanà: insight meditation. The knowledge you gain from Right Concentra tion doesnt come in the form of thoughts or ideas. As for the way to the disbanding of stress, you see that the path youre following will, without a doubt, lead to Liberation. When you come to real ize the truth of these things in your heart, thats vipassanà-¤àõa. To put it even more simply: You see that all things, inside as well as out, are undependable. Say we hear that a friend has become wealthy, and we become happy; or a son or daughter is ill, and we become sad. When you gain this sort of insight into stress — when you really see stress — vipassanà has arisen in the mind. As for anattà, not-self: Once weve examined things and seen them for what they really are, we dont make claims, we dont display infuence, we dont try to show that we have the right or the power to bring things which are not-self under our control. This is saïkhàråpekkhà-¤àõa: letting saïkhàra — all things fashioned, conditioned and caused — follow their own inherent nature. This, briefy, is vipassanà: You see that all things fashioned are inconstant, stressful and not self. To be attached means to carry a load, and there are fve heaps (khandha) we carry: attachment to physical phenomena, to feelings, to concepts and labels, to mental fashionings and to cognizance. The fve khandha are a heavy load, 90 91 bhàrahàro ca puggalo and as individuals we burden ourselves with them. The Buddha taught that whoever lacks discernment, whoever is unskilled, whoever doesnt practice con centration leading to liberating insight, will have to be burdened with stress, will always be loaded down. Soon theyll get discouraged, and then after a while theyll pick themselves up and get going again. Now, when we see inconstancy — that all things fashioned, whether within us or without, are undependable, when we see that theyre stress ful; when we see that theyre not our self, that they simply whirl around in and of themselves: When we gain these insights, we can put down our burdens, i. Observe the breath as it goes in and out, noticing whether its comfortable or uncomfortable, broad or constricted, obstructed or free-fowing, fast or slow, short or long, warm or cool. For instance, if breathing in long and out long is uncomfortable, try breathing in short and out short. As soon as you fnd that your breath feels comfortable, let this comfort able breath sensation spread to the different parts of your body. For example, when you breathe in and out once, think of an important part of the body, as follows: As you let the breath pass into the bronchial tubes, think of it as going all the way down the right side of your abdomen to the bladder. As you take another in-and-out breath, think of the breath as going from the main arteries to the liver and heart on down through your left side to the stomach and intestines. As you take another in-and-out breath, think of letting the breath go from the base of the throat down the front of your chest through to the tip of the breastbone, to the navel and out into the air. As you take another in-and-out breath, inhale the breath into the palate down to the base of the throat, on through the middle of the chest to the large intestine, the rectum and out into the air. Once youve completed these fve turns inside the body, let the breath fow along the outside of the body: As you take an in-and-out breath, think of inhaling the breath at the base of the skull and let ting it go all the way down the external (back) side of the spine. Now, if youre male, think frst of your right side, both with the legs and with the arms. As you take an in-and-out breath, think of the right buttock and of letting the breath run all the way down the right leg to the tips of your toes. As you take another in-and-out breath, think of the left buttock and of letting the breath run all the way down the left leg to the tips of your toes. As you take another in-and-out breath, think of the base of the skull and of letting the breath run 94 95 down your right shoulder, along your right arm to the tips of your fngers. As you take another in-and-out breath, inhale the breath into the base of the skull and let it run down your left shoulder, along your arm to the tips of your fngers. As you take another in-and-out breath, inhale the breath into the area inside your skull, thinking of your ears — eyes — nose — mouth. The word Noble (ariya) here can also mean ideal or standard, and in this phrase carries the meaning of objective or universal truth. There are four: stress, its cause, its disbanding, and the path of practice leading to its disbanding. Also, principles of behavior which human beings ought to follow so as to ft in with the right natural order of things; qualities of mind they should develop so as to realize the inherent quality of the mind in and of itself.

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Serious infections Serious infections buy discount levitra with dapoxetine 40/60 mg on-line impotence kidney disease, including sepsis purchase discount levitra with dapoxetine erectile dysfunction doctors in sri lanka, due to bacterial discount levitra with dapoxetine 40/60 mg erectile dysfunction protocol scam, mycobacterial, invasive fungal, parasitic, viral, or other opportunistic infections such as listeriosis, legionellosis and pneumocystis have been reported in patients receiving Humira. Other serious infections seen in clinical trials include pneumonia, pyelonephritis, septic arthritis and septicaemia. Tuberculosis Tuberculosis, including reactivation and new onset of tuberculosis, has been reported in patients receiving Humira. Before initiation of therapy with Humira, all patients must be evaluated for both active or inactive ( latent ) tuberculosis infection. This evaluation should include a detailed medical assessment of patient history of tuberculosis or possible previous exposure to people with active tuberculosis and previous and/or current immunosuppressive therapy. It is recommended that the conduct and results of these tests are recorded in the Patient Reminder Card. Prescribers are reminded of the risk of false negative tuberculin skin test results, especially in patients who are severely ill or immunocompromised. If active tuberculosis is diagnosed, Humira therapy must not be initiated (see section 4. In all situations described below, the benefit/risk balance of therapy should be very carefully considered. If latent tuberculosis is suspected, a physician with expertise in the treatment of tuberculosis should be consulted. If latent tuberculosis is diagnosed, appropriate treatment must be started with anti-tuberculosis prophylaxis treatment before the initiation of Humira, and in accordance with local recommendations. Use of anti-tuberculosis prophylaxis treatment should also be considered before the initiation of Humira in patients with several or significant risk factors for tuberculosis despite a negative test for tuberculosis and in patients with a past history of latent or active tuberculosis in whom an adequate course of treatment cannot be confirmed. Despite prophylactic treatment for tuberculosis, cases of reactivated tuberculosis have occurred in patients treated with Humira. Some patients who have been successfully treated for active tuberculosis have redeveloped tuberculosis while being treated with Humira. Patients should be instructed to seek medical advice if signs/symptoms suggestive of a tuberculosis infection (e. Other opportunistic infections Opportunistic infections, including invasive fungal infections have been observed in patients receiving Humira. For patients who develop the signs and symptoms such as fever, malaise, weight loss, sweats, cough, dyspnoea, and/or pulmonary infiltrates or other serious systemic illness with or without concomitant shock an invasive fungal infection should be suspected and administration of Humira should be promptly discontinued. Diagnosis and administration of empiric antifungal therapy in these patients should be made in consultation with a physician with expertise in the care of patients with invasive fungal infections. For patients who test positive for hepatitis B infection, consultation with a physician with expertise in the treatment of hepatitis B is recommended. Prescribers should exercise caution in considering the use of Humira in patients with pre existing or recent-onset central or peripheral nervous system demyelinating disorders; discontinuation of Humira should be considered if any of these disorders develop. There is a known association between intermediate uveitis and central demyelinating disorders. Neurologic evaluation should be performed in patients with non-infectious intermediate uveitis prior to the initiation of Humira therapy and regularly during treatment to assess for pre-existing or developing central demyelinating disorders. Allergic reactions Serious allergic reactions associated with Humira were rare during clinical trials. Non-serious allergic reactions associated with Humira were uncommon during clinical trials. Reports of serious allergic reactions including anaphylaxis have been received following Humira administration. If an anaphylactic reaction or other serious allergic reaction occurs, administration of Humira should be discontinued immediately and appropriate therapy initiated. There is an increased background risk for lymphoma and leukaemia in rheumatoid arthritis patients with long-standing, highly active, inflammatory disease, which complicates the risk estimation. The other cases represented a variety of different malignancies and included rare malignancies usually associated with immunosuppression. Rare postmarketing cases of hepatosplenic T-cell lymphoma have been identified in patients treated with adalimumab. This rare type of T-cell lymphoma has a very aggressive disease course and is usually fatal. Some of these hepatosplenic T-cell lymphomas with Humira have occurred in young adult patients on concomitant treatment with azathioprine or 6-mercaptopurine used for inflammatory bowel disease. The potential risk with the combination of azathioprine or 6-mercaptopurine and Humira should be carefully 50 considered. A risk for the development of hepatosplenic T-cell lymphoma in patients treated with Humira cannot be excluded (see section 4. No studies have been conducted that include patients with a history of malignancy or in whom treatment with Humira is continued following development of malignancy. Thus additional caution should be exercised in considering Humira treatment of these patients (see section 4. With current data it is not known if adalimumab treatment influences the risk for developing dysplasia or colon cancer. All patients with ulcerative colitis who are at increased risk for dysplasia or colon carcinoma (for example, patients with long-standing ulcerative colitis or primary sclerosing cholangitis), or who had a prior history of dysplasia or colon carcinoma should be screened for dysplasia at regular intervals before therapy and throughout their disease course. This evaluation should include colonoscopy and biopsies per local recommendations. Adverse events of the haematologic system, including medically significant cytopenia (e. All patients should be advised to seek immediate medical attention if they develop signs and symptoms suggestive of blood dyscrasias (e. Discontinuation of Humira therapy should be considered in patients with confirmed significant haematologic abnormalities.

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Longer radiographic differential follow-up is required laxity not significantly to confirm these first different between results buy generic levitra with dapoxetine 40/60mg erectile dysfunction doctor cape town. May be meniscecto instructions compared driven by 1 my with written and verbal outlier purchase discount levitra with dapoxetine on line erectile dysfunction just before intercourse, but instructions alone in medians not the early period after provided generic 40/60mg levitra with dapoxetine with amex erectile dysfunction in early 30s. Both the intervention and control groups improved similarly overall, revealing no benefit in receiving a mean of 12 standardized treatment sessions postsurgery over written and verbal advice. We therefore conclude that for an uncomplicated arthroscopic partial meniscectomy, routine physical therapy intervention is not indicated. The xenon chloride excimer laser is the best treatment for Copyright 2016 Reed Group, Ltd. The knee conservative patellofemoral splint; vastus lateralis splint used here is therapy pain syndrome 240±13. Isometric 60º (pre/3 The results indicate Some baseline 1997 females age eccentric muscle months/12 months): that the differences. Taping Ryan N/A N = 25 Lateral glide Vastus medialis The magnitude of Experimental 2006 asymptomatic taping vs. Average basic training straightens and change in pain from improves 2nd to 3rd visit: Group tracking and A: average change assist in 0. Unclear was superior to descriptive pain placebo whether baseline placebo in the data. No functional improvement management of mention of after treatment favored patients with chronic compliance in shockwave group, p patellar control group. Noncontact anterior cruciate ligament injuries: risk factors and prevention strategies. Effects of activity strategy training on pain and physical activity in older adults with knee or hip osteoarthritis: a pilot study. Reason for Visits to Emergency Room – National Hospital Ambulatory Medical Care Survey 1998-2006. Department of Health and Human Services; Centers for Disease Control and Prevention; National Center for Health Statistics. Internal derangement of the knee: diagnosis by arthrography, arthroscopy, and arthrotomy. Risk factors for onset of osteoarthritis of the knee in older adults: a systematic review and meta-analysis. The treatment and prevention of knee osteoarthritis: a tool for clinical decision making. Weight loss maintenance in severely obese adults after an intensive lifestyle intervention: 2 to 4-year follow-up. Effect of an exercise and dietary intervention on serum biomarkers in overweight and obese adults with osteoarthritis of the knee. Patient and provider factors related to comprehensive arthritis care in a community setting in Ontario, Canada. Obesity and osteoarthritis: disease genesis and nonpharmacologic weight management. Obesity and osteoarthritis: disease genesis and nonpharmacologic weight management. Exercise and dietary weight loss in overweight and obese older adults with knee osteoarthritis: the Arthritis, Diet, and Activity Promotion Trial. Inflammatory biomarkers and physical function in older, obese adults with knee pain and self-reported osteoarthritis after intensive weight-loss therapy. Quality and consistency of clinical practice guidelines for diagnosis and management of osteoarthritis of the hip and knee: a descriptive overview of published guidelines. The effects of exercise and weight loss in overweight patients with hip osteoarthritis: design of a prospective cohort study. Risk factors associated with the loss of cartilage volume on weight-bearing areas in knee osteoarthritis patients assessed by quantitative magnetic resonance imaging: a longitudinal study. A case referent study of body mass index, smoking and hormone therapy in 503 Swedish women. Relationships between body mass indices and surgical replacements of knee and hip joints. Physical therapy and rehabilitation programs in the management of hip osteoarthritis. Monocyte chemoattractant protein-1 is produced in isolated adipocytes, associated with adiposity and reduced after weight loss in morbid obese subjects. Weight loss reduces knee-joint loads in overweight and obese older adults with knee osteoarthritis. Change in body fat, but not body weight or metabolic correlates of obesity, is related to symptomatic relief of obese patients with knee osteoarthritis after a weight control program. A missense mutation in the aggrecan C-type lectin domain disrupts extracellular matrix interactions and causes dominant familial osteochondritis dissecans. Results of arthroscopic excision of the fragment in the treatment of osteochondritis dissecans of the knee. Osteochondral fractures and their relationship to osteochondritis dissecans of the knee. Osteochondritis dissecans and anomalous centres of ossification: a review of 80 lesions in 61 patients. The effects of articular, retinacular, or muscular deficiencies on patellofemoral joint stability. Comparison of three active therapies for chronic low back pain: results of a randomized clinical trial with one-year follow-up.

References:

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