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Jeffrey A Brinker, M.D.

Jeffrey A Brinker, M.D.

  • Professor of Medicine
  • Joint Appointment in Radiology and Radiological Science


After a weekend drinking binge 50 mg stendra fast delivery mens health 7 day workout plan, a 45-year-old man presents to cheap stendra online prostate test the hospital with abdominal pain safe stendra 100mg prostate cancer active surveillance, nausea, and vomiting. On physical examination, the patient is noted to have tenderness to palpation in the epigastrium. A 54-year-old man presents with sudden onset of massive, painless, recurrent hematemesis. Upper endoscopy is performed and reveals bleeding from a lesion in the proximal stomach that is characterized as an abnormally large artery surrounded by normal-appearing gastric mucosa. Which of the following is the most appropriate surgical management of this patient During an appendectomy for acute appendicitis, a 4-cm mass is found in the midportion of the appendix. Which of the following findings is most likely to be associated with the carcinoid syndrome It demonstrates a large gallstone in the cystic duct but also a polypoid mass in the fundus. Which of the following is an indication for cholecystectomy for a polypoid gallbladder lesion An alcoholic man has been suffering excruciating pain from chronic pancreatitis recalcitrant to analgesics and splanchnic block. A patient who has a total pancreatectomy might be expected to develop which of the following complications Which of the following is the most appropriate management strategy for this patient A 61-year-old woman with a history of unstable angina complains of hematemesis after retching and vomiting following a night of binge drinking. Endoscopy reveals a longitudinal mucosal tear at the gastroesophageal junction, which is not actively bleeding. Which of the following is the next recommended step in the management of this patient Expectant management Questions 362 to 365 Select the most appropriate diagnosis for each patient. On laboratory findings he has elevated levels of bilirubin and alkaline phosphatase. A 36-year-old woman presents with right upper quadrant abdominal pain and jaundice. On laboratory results she has leukocytosis and elevated levels of bilirubin and alkaline phosphatase. Ultrasound demonstrates gallstones, normal gallbladder wall thickness, no pericholecystic fluid, and a common bile duct of 1. On laboratory results he has no leukocytosis and normal levels of bilirubin, alkaline phosphatase, amylase, and lipase. On laboratory results she has no leukocytosis with normal levels of bilirubin and alkaline phosphatase. Ultrasound demonstrates gallstones, normal gallbladder wall thickness, no pericholecystic fluid, and a common bile duct of 3 mm. Questions 366 to 369 Select the most appropriate surgical procedure for each patient. A 37-year-old man with a 10-year history of ulcerative colitis who has a sessile polyp 10 cm from the anal verge with high-grade dysplasia. A 60-year-old woman with recurrent squamous cell carcinoma of the anus after chemoradiation. A 68-year-old woman with fecal incontinence who presents with a large fixed adenocarcinoma 3 cm from the anal verge. A 33-year-old man with a history of Crohn disease presents with severe abdominal pain and fever. On examination, his heart rate is 130 beats per minute, blood pressure 105/62 mm Hg, and 3 temperature 38. Omeprazole’s duration of action exceeds 24 hours, and doses of 20 to 30 mg/day inhibit more than 90% of 24-hour acid secretion. Omeprazole provides excellent suppression of mealstimulated and nocturnal acid secretion and seems very safe for short-term therapy. Prolonged administration in laboratory animals has been associated with significant hypergastrinemia, hyperplasia of enterochromaffinlike cells, and carcinoid tumors. Of these patients, those with a platelet count between 30,000 and 50,000/L have an increased risk for more severe thrombocytopenia. Patients with a platelet count lower than 30,000/L or less than 50,000/L with significant bleeding or risk factors for bleeding should be treated. Initial medical treatment with prednisone (1 mg/kg), and intravenous immunoglobulin is used in patients with severe bleeding or preoperatively prior to splenectomy. Splenectomy is indicated in patients who have severe symptomatic thrombocytopenia, patients in whom remission is achieved only with toxic doses of steroids, patients with a relapse after initial steroid therapy, patients with persistent thrombocytopenia for more than 3 months and a platelet count less than 30,000/L, and possibly in patients with a persistent platelet count of less than 10,000/L after 6 weeks of therapy. The platelet count can be expected to rise shortly after splenectomy, and prolonged remissions are expected in approximately two-thirds of cases. Often affecting older patients, they may present with symptoms mimicking those of acute appendicitis. A thorough initial workup and follow-up are necessary because of the high rate of synchronous and metachronous tumors. The safest and most effective treatment for this condition is surgical treatment with an esophagomyotomy.


  • Benzodiazepine dependence
  • Bantu siderosis
  • Keratosis palmoplantaris with corneal dystrophy
  • 46 xx gonadal dysgenesis epibulbar dermoid, rare (NIH)
  • Congenital arteriovenous shunt
  • Acute renal failure
  • Occupational asthma - wood
  • Left ventricular hypertrophy
  • Ruvalcaba Churesigaew Myhre syndrome
  • Craniosynostosis autosomal dominant

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The ability to buy genuine stendra prostate 40 gpa scale grasp the consequences of accepting and of declining the suggested treatment order stendra overnight prostate cancer 9 gleason score. Medical problems can sometimes be anticipated and a decision made in advance about what approach to buy genuine stendra on line prostate optimizer use when they develop. As an example, individuals who have had a stroke which impairs swallowing can be expected to develop problems with aspiration; the issue of gastrostomy tube feeding is appropriate to raise in these cases, even before any complications have actually developed. An unfocused or unstructured investigation of anemia can be costly and inefficient. Red blood cell loss Obvious (trauma, metro/menorrhagia) or Occult (polyp, cancer) b. Macrocytic (B12folate deficiency) Key Objectives 2 In iron deficiency anemia exclude the possibility of serious gastrointestinal disease. In a patient who is bleeding but refuses a blood transfusion, determine whether the decision can be justified within the context of a relatively stable set of values. For example, if the patient is delusional as a result of the blood loss, or is psychotic, the capacity to give informed consent should be questioned, and a substitute decision-maker should be identified. A very small proportion of the renal failure patient population receiving erythropoetin for treatment of anemia has developed pure red cell aplasia. Although studies have not identified the cause with certainty, the method of manufacture of the hormone, storage or method of administration, together or singly have been considered a possible cause. Patients receiving this drug need to know about the small risk involved and as a consequence have a choice in changing the type of medication or route/manner of administration pending identification of the cause. Prenatal diagnosis of sickle cell disease and thalassemia has been feasible for over 15 years and raises difficult ethical issues for parents and physicians. The decision to receive prenatal diagnosis is influenced by culture, religion, educational level, and the number of children in the family. Access to prenatal genetics services for the general population is important lest genetic screening become limited to the affluent. This has the potential of creating a situation wherein genetic disability becomes an indication of social class. Discuss erythropoesis within the bone marrow under the influence of the stromal framework, cytokines, and erythropoetin, a hormone produced in the kidney by cells that sense the adequacy of tissue oxygenation relative to need. Discuss the regulation of iron balance, availability of cobalamin and folic acid, and their absorption and anatomical site of absorption. Erythropoetin secreting tumor (hepato-cellular, renal cell, ovarian, uterine, hemangioblastoma) B. Relative polycythemia (decreased plasma volume: burns, diarrhea) Key Objectives 2 Since the most common cause of polycythemia is hypoxia secondary to pulmonary disease, elicit symptoms pertaining to altered lung function. Objectives 2 Through efficient, focused, data gathering: ­ Differentiate between causes of secondary erythrocytosis in patients without polycythemia related features. Ask about dyspnea, cough, cyanosis, hypersomnolence, long periods at high altitude, home oxygen therapy, history of heart or lung disease, family history, smoking history, exposure to carbon monoxide, or renal transplantation. Discuss whether the determination of red cell mass and plasma volume is necessary for the diagnosis of polycythemia or do measurements of hemoglobin levels to convey similar information. However, if accompanied by virilization, then a full diagnostic evaluation is essential because it is androgen-dependent. Hypertrichosis on the other hand is a rare condition usually caused by drugs or systemic illness. Objectives 2 Through efficient, focused, data gathering: ­ Determine which patients with recent onset of hirsutism require investigation. Identify the ovaries or adrenal as the site of increased androgen production in patients with hirsutism. Those who have correct word choice and syntax but have speech disorders may have an articulation disorder. However, if it lasts more than 2 weeks, especially in patients who use alcohol or tobacco, it needs to be evaluated. Tongue paralysis/Macroglossia (cranial polyradiculitis, allergic edema, stroke) ii. Silent/Non-speaking (catatonia/autism, depression, brainstem encephalitis) Key Objectives 2 Determine whether the speech apparatus is intact and the speech disorder is central. Objectives 2 Through efficient, focused, data gathering: ­ Elicit information indicative of inflammation/infection, voice abuse or misuse, smoking or alcohol. Identify the three main functions of the larynx as voice generation, airway protection from ingested material during swallowing, and cough production. Outline the anatomy of the hypopharynx, which extends from the base of the tongue to the upper cervical trachea and includes the larynx. It is crucial to distinguish acidemia due to metabolic causes from that due to respiratory causes; especially important is detecting the presence of both. Management of the underlying causes and not simply of the change in [H+] is essential. Outline how pulmonary and renal excretion of carbon dioxide and non-volatile acid respectively maintain body acid base balance. Outline the 3 different ways available to buffer secreted [H+] in the renal tubule. Contrast the value of urinary sodium concentration to that of chloride as a surrogate for volume status. Both partners must be investigated; male-associated factors account for approximately half of infertility problems. Although current emphasis is on treatment technologies, it is important to consider first the cause of the infertility and tailor the treatment accordingly.

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Komi’s classification of anomalous union between found in 82% of infant patients buy 50 mg stendra with mastercard prostate cancer leg pain, but few of the patients pancreatic and bile ducts 100 mg stendra with amex prostate removal. Both types were subdivided into “a” and “b” according common findings are abdominal pain stendra 50mg lowest price mens health home workout bible pdf, fever, jaundice to whether the common channel was dilated or not. Abdominal pain is the most comthe common bile duct and the pancreatic ducts formed a common symptom in adult patients, with an incidence rangplicated network. Jaundice, nausea, and cholangitis show’s classification of dominant dorsal pancreatic duct. Takase / Open Journal of Gastroenterology 2 (2012) 145-154 connected to the ducts of the ventral pancreas by analyzthe pancreatic head with choledochal cysts. Redundant pancreatic tissue has been found in the head of the pancreas with choledochal cysts. The component of this portion is different from that of the right ventral pancreas or dorsal pancreas. It is unknown whether this portion of redundant pancreatic tissue is derived from the ventral or dorsal anlage. In chickens and frogs, the left ventral anlage persists, and the two ventral buds fuse together and become part of the mature organ [58,59]. Considering the development of other species, such as frogs, chickens and mammals, this redundant pancreatic tissue appears to be derived from the left ventral anlage [29,50]. Choledochal cysts might occur when the left ventral anlage persists and recanalization of the bile ducts is disrupted. Delayed recanalization of the intraor extra-hepatic bile ducts leads to dilatation of the bile ducts (Figure 4). In normal embryonic (a) fusion, the ventral anlage is fused with the dorsal anlage side by side. The major papilla was located in the distal portion of the duodenum in approximately 70% of patients with choledochal cysts [62, 63]. The ventral (c) pancreatic anlage is initially paired, with the left lobe subsequently disappearing during development. Takase / Open Journal of Gastroenterology 2 (2012) 145-154 does not use ionizing radiation and a contrast agent, it is still had symptoms in 65% of them, and a second operathe first-choice modality in pediatric patients with chotion was required in 40% of patients [82]. Other complitype of invasive direct cholangiography, which may be cations, including stone formation, pancreatitis, portal associated with significant morbidity and mortality [69]. A surgical procedure without cyst excision difficulty in depicting peripheral bile ducts and small does not diminish malignant potential [83]. Postoperative sizes of pancreatic ducts and small duct abnormalities, risk without cyst excision has been reported by many because of decreased spatial resolution, or a physiologisurgeons. The risk of reoperation of internal drainage (50%) dilatation, and filling defects larger than 3 mm, but there is higher than that of cyst excision (6. A revisional operation should be performed in first-choice modality for diagnosing choledochal cysts patients previously treated by cystoenterostomy. The incidence of recurrent cholangitis, intraparticularly useful for showing continuity with bile ducts hepatic calculi, and postoperative stricture has improved and diagnosis of cyst rupture in patients with choledosignificantly with this procedure [85]. Hepatobiliary scintigraphy complements other the incidence of cholangitis after surgery decreases diagnostic tools in the diagnosis of choledochal cysts in from 88% (internal drainage) to 2. Postoperative complications, the treatment of choice for choledochal cysts is removal including postoperative cholangitis and intra-hepatic of the cysts by surgery. A wide anastomosis has not been performed, because of complications after between the hepatic hilum and intestine may prevent surgery, including recurrent cholangitis, intrahepatic calanastomotic stricture. A the incidence of postoperative complications varies high incidence of complications after internal drainage with age, surgical procedure, and institutions. Chijiiwa and Koga reported complicadence of postoperative complications in children (9. Takase / Open Journal of Gastroenterology 2 (2012) 145-154 151 complication rate is as low as 7% compared with that of [7] Howard, E. In summary, complete excision late complications related to Todani’s classification. Jourof cysts is an adequate standard treatment for Types I and nal of Pediatric Surgery, 37, 1568-1573. Surgery, Gynecology & Obstetrics, 164, 61choledochal cysts are classified based on radiological 64. Anatomical and pathological findings of Carcinomas arising in cystic conditions of the bile ducts. Journal of Hepato-Biliary-Pancreatic dochal cysts has changed over time because of post-opSurgery, 10, 345-351. Journal of the American College of Surgeons, 206, 1000-1005; discussion 1005-1008. International Abstracts of Surgery, choledochocele: Correlation of radiological, clinical and 108, 1-30. Multimodality imaging of pancreatic and biliary conArchives of Surgery, 138, 333-339. Canadian Jourmaljunction Journal of Hepato-Biliary-Pancreatic Surnal of Surgery, 52, 506-511. Annales de creaticobiliary maljunction: Etiologic concepts based on Radiologie (Paris), 12, 231-240. American Jourpathology of idiopathic cystic dilatation of the common nal of Roentgenology, 128, 571-577. Gastrointestinal Endoscopy, 55, 204creatic polypeptide islets and glucagon islets: Distinct 208. Takase / Open Journal of Gastroenterology 2 (2012) 145-154 153 Hebdomadaires des Seances de l’Academie des Sciences, with high-resolution multiplanar reformatted images in Serie D, 283, 1213-1216. Developmental Dynamics, 218, nosis of anomalous pancreaticobiliary junction: Value of 615-627.

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Should the ultrasound beam encounter tissues or objects with very different acoustic properties to cheap stendra online american express mens health magazine recipes general soft tissues buy stendra with a mastercard prostrate knotweed family. If an adequate number of points can be transmitted and received buy stendra canada prostatic urethra, a composite image of the reflecting surfaces can be displayed. This image is updated by sending multiple pulses and receiving multiple echoes in a relatively short period. The data are stored in a computer and, when transferred to a video display in “real time,” a moving, flicker-free image can be seen. This real-time image can be recorded on videotape or the video display can be “frozen” on an area of interest and recorded on photographic film or electronic media for future computer-based transfer, manipulation, and even transmission to a remote site for second opinion. The echoes reflected from a body part being examined also can be displayed along a moving, time-oriented graph. This display is referred to as M-mode and is used most often in cardiology to display quantitatively the size of heart valves,heart chambers,heart walls,and great vessels, as well as the motion of the ventricular walls, heart valves, and major vessels. The striplike image that is created parallels the course of an electrocardiogram, which also allows comparison of electrical and mechanical cardiac activities. In general, the higher the resonant frequency the greater the resolution but the lower the penetration of the sound beam. The arrangement of the piezoelectric crystals as well as their number, “firing” sequence and, if applicable, motion determines the shape of the two-dimensional image display. The applicability of these transducer configurations depends on whether a small or large “footprint,” or area of surface contact, is applicable to the anatomy being imaged and the cost one is willing to encumber for a machine. Current sector scanners may have transducer configurations ranging, in increasing order of cost, from (1) mechanical sector, moving the piezoelectric crystal(s), through (2) curved linear/radial array, a series of piezoelectric crystals arranged in a diverging array, to (3) phased array, a linear series of piezoelectric crystals pulsed in a highly sophisticated sequence to whip the sound beam back and forth (Fig. Current linear-array scanners (linear series of piezoelectric crystals designed to image flat or nearly flat surfaces and yield a rectangular image that corresponds to the transducer length) may vary in their overall size depending on their intended use. The most versatile transducer configuration for small animal imaging is the sector scan because the narrow part of the image is at the skin surface and the viewed area gets wider with increasing depth in the patient. The ventral capsule (arrow closest to top) and dorsal capsule (arrow lowest on scan and pointing to the entrance of a splenic vein) are identified. Note the difference in the volume imaged in the near field (just under the skin surface) in A compared with B. A B tions available including transvaginal, transesophageal, and even intravascular. These are, however, quite expensive and are designed only for specific use in humans. Although there may be some applicability of these to select small animal situations, their limited versatility usually does not justify their cost. These have been described in detail, and the physical principles governing their production have been explained. Interpretation may lead to a specific diagnosis, but more often it leads to the development of a list of differential diagnoses based on the radiographic findings. Next, the clinician should compare the list of differential diagnoses with the possible diagnoses based on the patient’s history and physical findings. Finally, given all the data, a radiographic diagnosis or list of probable diagnoses should be developed. From this list, a plan for additional tests or further radiographic studies should be developed either to confirm or refute the possible diagnoses or to establish a treatment plan. In most cases a radiographic examination precedes the ultrasonographic examination. The size, shape, location, echo intensity, and homogeneity of the ultrasonographic images are evaluated and compared to the radiographic interpretation and other available information. As in radiography, a list of differential diagnoses is developed and from this list a diagnostic or therapeutic plan is developed. Specific diagnoses may, however, be facilitated using tissue core biopsy or fine-needle aspirates obtained with ultrasonographic guidance. To date, attempts to correlate sonographic architecture and echo intensity with histological diagnoses have been generally unsuccessful. Instead, a list of differential diagnoses will be developed based on the ultrasonographic findings and other available information. Radiographs provide excellent anatomical information but are of limited use in the evaluation of some tissues or organs. For example, the internal structure of the liver cannot be examined using noncontrast radiographic techniques. Noncontrast, noncomputed radiographic techniques can differentiate only five relative patient or object densities. These are, in increasing order of radiographic absorption: air, fat, water or soft tissue, bone, and Chapter One Introduction 5 metal. Soft tissues or organs surrounded by fluid cannot be defined, because their tissue density is the same as that of the fluid surrounding them. The internal architecture of organs is similarly obscured due to the aggregation of similarly dense tissues inside a given organ. Patient manipulation, as well as the addition of appropriately administered positive (more opaque than soft tissue) or negative contrast (less opaque than soft tissue) media may facilitate the radiographic assessment. Be sure appropriate indications and contraindications for these media are understood. Ultrasonography is superior to radiography in some circumstances but has limitations in other areas. Ultrasonography provides information about size, shape, and location of structures; however, it also provides information about the soft-tissue architecture of the structure or organ being examined. Ultrasonography is best for distinguishing solid from cavitating (fluid-filled) structures and provides internal detail not demonstrated radiographically. When identified, an abdominal mass should be evaluated to determine (1) its internal architecture, particularly whether the mass is solid or cavitating, (2) the organ from which the mass arises, (3) the extent of that organ infiltrated, (4) the degree of local spread.

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A number of researchers have investigated this issue further buy stendra online pills prostate oncology veterinarians, mainly using animal models purchase stendra 50 mg line mens health yoga workout. Additionally 50 mg stendra with visa prostate health vitamins, cholesterol and triglyceride lowering activity has been reported (Yu et al 2002). Clearly, due to the potent antioxidant activity of grapeseed, its therapeutic potential is quite broad. Most clinical studies have been conducted in Europe using a commercial product known as Endotelon. Hormone replacement therapy and fluctuations in hormone levels can produce symptoms of venous insufficiency in some women. Symptoms of itching and pain responded best, completely disappearing during the course of treatment in 80% and 53% of the patients respectively (Costantini et al 1999). In some pathological conditions, such as inflammation or diabetes, vascular permeability can be abnormally increased (Robert et al 1990). These results were obtained by measuring objective markers such as visual acuity, muscular tone, and ocular tone. Grapeseed extract (Endotelon) has also been shown significantly to improve visual adaptation to and from bright light in a dual centre study involving 100 volunteers (Boissin et al 1998, Corbe et al 1988). Chloasma Chloasma is a condition characterised by hyperpigmentation and is generally considered recalcitrant to treatment. The study continued for another 6 months but failed to find an additional improvement with further use. This appears to be positively associated with an increase in plasma antioxidant activity. Tannins can bind to iron, forming insoluble complexes — separate doses by 2 hours. It is also used to relieve eye strain, stabilise diabetic retinopathy and connective tissue disorders. Possible benefits in pancreatitis and multi-organ protection against © 2007 Elsevier Australia damage caused by several pharmaceutical drugs. It is also used to treat eye strain, diabetic retinopathy, and enhance wound healing when applied locally. It appears to relieve symptoms of venous insufficiency within 10 days and eye strain within 5 weeks. Research suggests it is well tolerated and generally safe; however, people taking anticoagulant medicines should refer to their healthcare professional before taking this substance. Endotelon in the treatment of venolymphatic problems in premenstrual syndrome: multicenter study on 165 patients. Contribution to the study of procyanidolic oligomers: Endotelon in diabetic retinopathy. Oxygen free radical scavenging abilities of vitamins C and E, and a grape seed proanthocyanidin extract in vitro. Free radicals and grape seed proanthocyanidin extract: importance in human health and disease prevention. Molecular mechanisms of cardioprotection by a novel grape seed proanthocyanidin extract. Antioxidant activity and radioprotective effects against chromosomal damage induced in vivo by X-rays of flavan-3-ols (procyanidins): from grape seeds (Vitis vinifera): comparative study versus other phenolic and organic compounds. Diet enriched with procyanidins enhances antioxidant activity and reduces myocardial postischaemic damage in rats. Comparative study of radical scavenger and antioxidant properties of phenolic compounds from Vitis vinifera cell cultures using in vitro tests. Oligomeric proanthocyanidin complexes: history, structure, and phytopharmaceutical applications. The cellular and molecular basis of health benefits of grape seed proanthocyanidin extract. Chemoprevention by grape seed extract and genistein in carcinogen-induced mammary cancer in rats is diet dependent. Free radicals scavenging action and anti-enzyme activities of procyanidines from Vitis vinifera: A mechanism for their capillary protective action. Procyanidines from Vitis vinifera seeds protect rabbit heart from ischemia/reperfusion injury: antioxidant intervention and/or iron and copper sequestering ability. Chemoprevention of colorectal cancer by grape seed proanthocyanidin is accompanied by a decrease in proliferation and increase in apoptosis. Effects of niacin-bound chromium and grape seed proanthocyanidin extract on the lipid profile of hypercholesterolemic subjects: a pilot study. Dietary proanthocyanidins: occurrence, dietary intake, bioavailability, and protection against cardiovascular disease. Proanthocyanidin exposure to B6C3F1 mice significantly attenuates dimethylnitrosamine-induced liver tumor induction and mortality by differentially modulating programmed and unprogrammed cell deaths. Regulation of inducible adhesion molecule expression in human endothelial cells by grape seed proanthocyanidin extract. Grape seed and grape skin extracts elicit a greater antiplatelet effect when used in combination than when used individually in dogs and humans. Evidence by in vivo and in vitro studies that binding of pycnogenols to elastin affects its rate of degradation by elastases. Grape seed and skin extracts inhibit platelet function and release of reactive oxygen intermediates. Supplementation with grape seed polyphenols results in increased urinary excretion of 3hydroxyphenylpropionic acid, an important metabolite of proanthocyanidins in humans. Antiexudative and capillaritonic effects of procyanidines isolated from grape seeds (V. Proanthocyanidin from grape seeds potentiates anti-tumor activity of doxorubicin via immunomodulatory mechanism.


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