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Jeffrey A Brinker, M.D.

Jeffrey A Brinker, M.D.

  • Professor of Medicine
  • Joint Appointment in Radiology and Radiological Science

https://www.hopkinsmedicine.org/profiles/results/directory/profile/0001297/jeffrey-brinker

Early and late term management in caustic ingestion in children: a 16-year experience buy 10g contractubex. A standardised protocol for the acute management of corrosive ingestion in children buy contractubex now. Low dose subcutaneous adrenaline to prevent acute adverse reactions to antivenom serum in people bitten by snakes: randomised purchase cheap contractubex on line, placebo controlled trial. Effects of topical heparin, antivenom, tetracycline and dexamethasone treatment in corneal injury resulting from the venom of the black spitting cobra (Naja sumatrana), in a rabbit model. Honeybees and caterpillars: epidemiology of accidents involving these animals in the Criciuma region, southern Santa Catarina State, Brazil. Insect venom hypersensitivity: experience in a clinical immunology/allergy service in Singapore. Emergency Department Evaluation and Treatment for Children With Arthropod Envenomations: Immunologic and Toxicologic Considerations. American Academy of Pediatrics point of care quick reference, last updated Jul 24, 2008. Severe late clinical manifestations after hornet (Vespa orientalis) stings-in a young child. Therapeutic and toxic blood concentrations of more than 800 drugs and other xenobiotics. Therapeutic, toxic, and lethal concentrations in human uids of 90 drugs affecting the cardiovascular and hematopoietic systems. Therapeutic, toxic, and lethal concentrations of 73 drugs affecting respiratory system in human uids. Concentrations in human uids: 101drugs affecting the digestive system and metabolism. Case of intractable ventricula brillation by a multicomponent dietary supplement containing ephedra and caffeine overdose. Adulteration by synthetic therapeutic substances of traditional Chinese medicines in Taiwan. Adulteration of Chinese herbal medicines with synthetic drugs: a systematic review. Clinical approach to adverse events and interactions related to herbal and dietary supplements. Recent patterns of medication use in the ambulatory adult population of the United States: the Slone survey. The following statements about single dose activated charcoal are true: A) Single dose activated charcoal is effective for iron poisoning. C) Studies have shown that single dose activated charcoal is useful as a gastric decontaminant within 1 hour following ingestion of a potentially toxic amount of a poison. E) Combined use of ipecac and activated charcoal is more effective than use of either one of these agents by themselves. C) Patients with respiratory insufciency should be supported with bag mask ventilation and 100 percent oxygen to correct respiratory acidosis before or while naloxone is administered in a patient with suspected opioid poisoning. D) A 3 year old child can be observed at home if accidentally ingested only 1 mL of medicated ointment with methylsalicylate. E) Intubation should be done to prevent respiratory fatigue in an alert 50 year old female with witnessed salicylate poisoning presenting with severe shortness of breath and respiratory rate of 46/min. The following is/are true of paracetamol poisoning: A) A single acute ingestion of 200mg/kg/day or more for both children and adults is considered toxic ingestion. B) Repeated oral ingestion totaling 150mg/kg/day for children more than 6 years old or adults with no risk factors is considered toxic ingestion. C) Activated charcoal via nasogastric tube should be given to a drowsy 40kg adolescent female who took 20 tablets of 500g of paracetamol 2 hours ago. D) Tere is no urgent need to start intravenous N-acetylcysteine in a combative patient with severe right abdominal pain with witnessed massive paracetamol ingestion 3 hours ago till serum levels are done with confrmed paracetamol toxicity afer 4 hours post ingestion. E) Once the 3-stage infusion of intravenous N-Acetylcysteine totaling 300mg/kg has been completed in patients with established paracetamol-induced hepatitis, there is no further use in continuing N-acetylcysteine. The following is/are true of antihistamine and anticholinergic poisoning: A) An asymptomatic 2 year old child who had accidentally ingested a single lomotil tablet should be observed in the hospital for at least 24 hours. C) Orphenadrine toxicity usually cause delirium, sedation, excitation and peripheral anticholinergic efects but no life threatening toxicity. D) Unlike amphetamine overdose, a delirious patient with anticholinergic toxicity will have tachycardia, hyperthermia delirium and anhidrosis. E) Sepsis can be easily diferentiated from the symptoms of anticholinergic toxicity. The following is/are true of the management of antihistamine and anticholinergic poisoning: A) Gastric lavage can be considered in massive anticholinergic overdose. B) Activated charcoal should be used in an agitated patient with distended abdomen if the anticholinergic overdose occurred 45 minutes ago. C) The cornerstone in managing moderate to severe anticholinergic poisoning is treatment with cholinergic agents. D) Physiostigmine can be considered in stable but agitated and delirious patients with no known cardiac, reactive respiratory airway disease or underlying cardiac disease with cardiac monitoring in the intensive care. E) Physiostigmine should be used in patients with seizures secondary to anticholinergic overdose. C) Current evidence is insufcient to indicate whether oximes are benefcial or harmful in the management of acute organophosphate poisoning in humans. Clinical features that suggest serious caustic ingestion include: A) Stridor B) Dysphagia C) Hematemesis D) Airway burns E) Accidental ingestion 332 Answers: 1 A) T 6 A) T B) F B) F C) T C) F D) T E) F D) T E) F 2 A) F 7 A) T B) T B) F C) T C) T D) F D) T E) F E) F 3 A) F 8 A) T B) F B) T C) T C) T D) F D) F E) F E) F 4 A) T llT B) T C) F D) F E) F 5 A) T 10 A) T B) T B) T C) T C) F D) F D) T E) F E) F 333 Workgroup members the members of the workgroup, who were appointed in their personal professional capacity, are: Chairman Dr R. Clubbing of the nails often suggests pulmonary disease or inflammatory bowel disease. Koilonychia, or “spoon-shaped” nails, may stimulate a work-up for hemochromatosis or anemia.

Homo cysteine and coronary artery disease in French Canadian subjects: Relation with vitamins B12 order generic contractubex on-line, B6 discount 10g contractubex mastercard, pyridoxal phosphate purchase 10g contractubex free shipping, and folate. Minimum effective dose of folic acid for food fortification to prevent neural tube defects. Effects of different enzyme treatments on extrac tion of total folate from various foods prior to microbiological assasy and radioassay. Dietary Reference Intakes: the Essential Guide to Nutrient Requirements. Food standards: Amendment of the standards of identity for enriched grain products to require the addition of folic acid. Food standards: Amendment of the standards of identity for enriched grain products to require addition of folic acid. Heterogeniety of neural tube defects in Europe: the significance of site of defect and presence of other major anoma lies in relation to geographic differences in prevalence. Folate and vitamin B12 concentrations in maternal and fetal blood, and amniotic fluid in second trimester pregnancies complicated by neural tube defects. Plasma and red cell folate values in newborn infants and their mothers in relation to gestational age. Plasma and red cell folate values and folate requirements in formula-fed term infants. Maternal methionine supplementation promotes the remediation of axial defects in Axd mouse neural tube mutants. Homocyst(e)ine and risk of cardiovascular disease in the Multiple Risk Factor Intervention Trial. The comparative efficacy and toxicity of second-line drugs in rheumatoid arthritis. Dietary Reference Intakes: the Essential Guide to Nutrient Requirements. A candidate genetic risk factor for vascular disease: A common mutation in methylenetet rahydrofolate reductase. Nutritional sta tus in a healthy elderly population: Dietary and supplemental intakes. Effect of chronologic age on induc tion of cystathionine synthase, uroporphyrinogen I synthase, and glucose 6 phosphate dehydrogenase activities in lymphocytes. First National Health and Nutrition Examination Survey epidemiology follow-up study. Colorectal cancer and folate status: A nested case control study among male smokers. Association between nutritional status and cognitive functioning in a healthy elderly population. Dietary Reference Intakes: the Essential Guide to Nutrient Requirements. Chemical and nutritional aspects of folate research: Analyti cal procedures, methods of folate synthesis, stability and bioavailability of di etary folates. Ad equacy of extraction techniques for determination of folate in foods and other biological materials. Experience with pteroylglutamic (synthetic folic acid) in the treatment of pernicious anemia. Metabolic effects and diagnostic value of small doses of folic acid and B12 in megaloblastic anemias. Symptomatic and asymptomatic methylenetetrahydro folate reductase deficiency in two adult brothers. Case-control study of pericon ceptional folic acid supplementation and oral clefts. Dietary Reference Intakes: the Essential Guide to Nutrient Requirements. Departmental Consolidation of the Food and Drugs Act and the Food and Drug Regulations with Amendments to December 19, 1996. Localized folic acid deficiency and bronchial metaplasia in smokers: Hypoth esis and preliminary report. Improvement in bronchial squamous metaplasia in smokers treated with folate and vitamin B12. Lack of toxicity of folic acid given in pharmacological doses to healthy volunteers. Making sense of laboratory tests of folate status: Folate require ments to sustain normality. Correlates of folate deficiency with alco holism and associated macrocytosis, anemia, and liver disease. Method of assay of red cell folate activity and the value of the assay as a test for folate deficiency. Recurrence of neural tube defect in a group of at risk women: A 10 year study of Pregnavite Forte F. Can terathanasia explain the protective effect of folic acid supplementation on birth defects Dietary Reference Intakes: the Essential Guide to Nutrient Requirements. Association between dietary fiber intake and the folate status of a group of female adolescents. Homocysteine increases as folate decreases in plasma of healthy men during short-term dietary folate and methyl group restriction. Folic acid therapy: Its effect as observed in two patients with pernicious anemia and neurologic symptoms.

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The Agriculture Department itself has credited these importations with appreciably reducing the frequency and destructiveness of gypsy moth outbreaks purchase contractubex 10g amex. This natural control discount contractubex 10g mastercard, plus quarantine measures and local spraying generic 10g contractubex otc, achieved what the Department in 1955 described as outstanding restriction of distribution and damage. Yet only a year after expressing satisfaction with the state of affairs, its Plant Pes t Control Division embarked on a program calling for the blanket spraying of several million acres a year with the announced intention of eventually eradicating the gypsy moth. Yet as successive programs have failed, the Department has found it necessary to speak of second or third eradications of the same species in the same area. In 1956 nearly a million acres were sprayed in the states of Pennsylvania, New Jersey, Michigan, and New York. Conservationists became increasingly disturbed as the pattern of spraying huge areas began to establish itself. When plans were announced for spraying 3 million acres in 1957 opposition became even stronger. State and federal agriculture officials characteristically shrugged off individual complaints as unimportant. The Long Island area included within the gypsy moth spraying in 1957 consisted chiefly of heavily populated towns and suburbs and of some coastal areas with bordering salt marsh. Nassau County, Long Island, is the most densely settled county in New York apart from New York City itself. In what seems the height of absurdity, the threat of infestation of the New York City metropolitan area has been cited as an important justification of the program. They sprayed the quarter-acre lots of suburbia, drenching a housewife making a desperate effort to cover her garden before the roaring plane reached her, and showering insecticide over children at play and commuters at railway stations. At Setauket a fine quarter horse drank from a trough in a field which the planes had sprayed; ten hours later it was dead. A group of Long Island citizens led by the world-famous ornithologist Robert Cushman Murphy had sought a court injunction to prevent the 1957 spraying. But because the act had already been performed the courts held that the petition for an injunction was moot. The contamination of milk and of farm produce in the course of the gypsy moth spraying came as an unpleasant surprise to many people. What happened on the 200-acre Waller farm in northern Westchester County, New York, was revealing. Waller had specifically requested Agriculture officials not to spray her property, because it would be impossible to avoid the pastures in spraying the woodlands. She offered to have the land checked for gypsy moths and to have any infestation destroyed by spot spraying. Although she was assured that no farms would be sprayed, her property received two direct sprayings and, in addition, was twice subjected to drifting spray. Forage samples from fields where the cows had grazed were of course contaminated also. Although the county Health Department was notified, no instructions were given that the milk should not be marketed. This situation is unfortunately typical of the lack of consumer protection that is all too common. Although the Food and Drug Administration permits no residues of pesticides in milk, its restrictions are not only inadequately policed but they apply solely to interstate shipments. State and county officials are under no compulsion to follow the federal pesticides tolerances unless local laws happen to conform—and they seldom do. Growers therefore had to sustain heavy losses or find themselves in the position of selling produce carrying illegal residues. Department of Agriculture and the agricultural colleges, one of them remarked bitterly. But in May of that year this man lost 800 colonies after the state had sprayed a large area. So widespread and heavy was the loss that 14 other beekeepers joined him in suing the state for a quarter of a million dollars in damages. Another beekeeper, whose 400 colonies were incidental targets of the 1957 spray, reported that 100 per cent of the field force of bees (the workers out gathering nectar and pollen for the hives) had been killed in forested areas and up to 50 per cent in farming areas sprayed less intensively. Because the spray planes were paid by the gallon rather than by the acre there was no effort to be conservative, and many properties were sprayed not once but several times. Contracts for aerial spraying were in at least one case awarded to an out-of-state firm with no local address, which had not complied with the legal requirement of registering with state officials for the purpose of establishing legal responsibility. In this exceedingly slippery situation, citizens who suffered direct financial loss from damage to apple orchards or bees discovered that there was no one to sue. After the disastrous 1957 spraying the program was abruptly and drastically curtailed, with vague statements about evaluating previous work and testing alternative insecticides. Instead of the 3 million acres sprayed in 1957, the treated areas fell to million in 1958 and to about 100,000 acres in 1959, 1960, and 1961. During this interval, the control agencies must have found news from Long Island disquieting. The expensive spraying operation that had cost the Department dearly in public confidence and good will—the operation that was intended to wipe out the gypsy moth for ever—had in reality accomplished nothing at all. Meanwhile, the Departments Plant Pest Control men had temporarily forgotten gypsy moths, for they had been busy launching an even more ambitious program in the South. The word eradication still came easily from the Departments mimeograph machines; this time the press releases were promising the eradication of the fire ant. The fire ant, an insect named for its fiery sting, seems to have entered the United States from South America by way of the port of Mobile, Alabama, where it was discovered shortly after the end of the First World War. By 1928 it had spread into the suburbs of Mobile and thereafter continued an invasion that has now carried it into most of the southern states. During most of the forty-odd years since its arrival in the United States the fire ant seems to have attracted little attention.

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The chromium amounts from ferrochromium were slightly higher than from the stainless steel order contractubex uk. The Cr release rate was significantly higher in artificial sweat than in the artificial tear fluid buy generic contractubex 10g. Iron release from stainless steel particles was significantly lower than from pure Fe metal proven 10g contractubex. The higher content of sulphur renders these stainless steels easier to machine but more susceptible to corrosion and nickel release, particularly in chloride containing media. The release rates from stainless steels were significantly lower than from pure 2 nickel or nickel plated steel (100 µg/cm /week). The release of nickel from four different stainless steel alloys into artificial saliva (pH 5. The lower pH of saliva results in potential corrosion of alloys and release of metal ions. Some reports present data on nickel release from stainless steel jewellery (Fischer, Fregert et al. However, no details on composition of stainless steels were presented, and the value of these studies is therefore limited. Some inhaled particles are removed from respiratory tract to gastrointestinal tract. Therefore, the metal release from stainless steel has been investigated in artificial lung fluids and gastric fluid. Exposure periods of 8 h, 1 d and 1 and 4 weeks were chosen and the releases of chromium, nickel and iron were measured by atomic absorption 30 spectroscopy. Analysis of the surface with X ray photoelectron microscopy was performed and samples were also evaluated visually. Metal release rates were highest in the beginning of the incubation and reached a steady state after 1 week. Nickel release was significantly higher from 303 than 304 only in artificial intracellular fluid. In addition, iron release was significantly higher from 303 than 304 only in artificial intracellular fluid. Measurement of the momentary corrosion rate was also performed by electrochemical polarization and impedance spectroscopy. These techniques revealed that after the initial high corrosion rate, a relatively constant low level was reached during the first week of exposure. The studies on surface chemistry showed that Cr was enriched on the surface, resulting in the formation and growth of a protective passive layer. This explains the decrease in the corrosion rate with time and the onset of a steady state. Seven stainless steel grades were studied in vitro to see whether there are differences in the release rates (Herting, Odnevall Wallinder et al. Grades 2205 (duplex), austenitic steels 201, 304, 310, 316L and ferritic steels 409, 430 were studied. Although stainless steel in massive form cannot be inhaled, it was considered appropriate to conduct screening tests to compare the dissolution of metals from different grades and surface finishes and to understand the parameters affecting the releases. In addition, surface analysis by X ray photoelectron spectroscopy was performed before and after incubation in order to see the effects on surface composition. The results show that the total release of 2 metals was very low from all grades of stainless steel (<5 g/cm /week). Ferritic grades had the highest total release rates, but this was caused only by the release of iron. Even though the chromium and nickel content of these 31 grades varied between 11. The results can be explained by the fact that the increased chromium content or alloying with nickel or molybdenum improves the corrosion resistance. This occurred with all grades and may be explained by increasing chromium content of the surface film. Good correlation with the chromium bulk content and total metal release was shown (Herting, Odnevall Wallinder et al. The total release rate of 2 metals was very low from both grades (<3 g/cm /week). Release rates (estimated from the articles 2 graphics) varied between 1–2 g/cm /week for iron and between 0. Low nickel grade showed somewhat higher total metal release and the release of iron, chromium and manganese, but the differences between very low quantities were less than two fold. Manganese was also present in the surface film at a relative amount (Mn/Cr+Fe+Mn+Ni) 0. As in the previous studies, the release of metals from all samples during one week was very low, with a total release 32 2 (Cr, Ni, and Fe) varying from 0. The release rate was higher in the early part of incubation (at 8 h time point), and decreased later. Nickel releases from stainless steel with different surface finishes did not vary whereas some variation was seen in iron and chromium releases. The variation in chromium oxide content of the surface, in the thickness of the passive film, surface roughness, or the geometric surface area did not correlate with release rates, whereas the variation in electrochemically active surface correlated. The differences between surface finishes were, however, very small and are unlikely to have any impact on the toxicity of stainless steel. Again iron was released at highest rate and it accounted for the differences in total metal release. Analysis of surface layer composition showed that observed small differences in release rates cannot be explained solely by changes in chromium content of the surface.

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The symp toms were described as being worse or the same after the frst dose com pared to the second dose by 8 of the 10 children 10g contractubex fast delivery. Evidence from these publications include latency of 24 hours between vaccination and the development of symptoms buy contractubex no prescription, complement activation buy contractubex with paypal, and importantly, recurrence of symptoms after vaccine rechallenge in six publi cations. In addition, the activation of the complement cascade by infuenza viruses directly through binding of its matrix (M1) protein (Zhang et al. Adverse Effects of Vaccines: Evidence and Causality 402 Copyright National Academy of Sciences. Adverse Effects of Vaccines: Evidence and Causality 403 Copyright National Academy of Sciences. Adverse Effects of Vaccines: Evidence and Causality 404 Copyright National Academy of Sciences. Infuenza virus vaccination of patients with systemic lupus erythematosus: Effects on disease activity. Infuenza vaccination in patients with asthma: Effect on peak expiratory fow, asthma symptoms and use of medication. Subunit infuenza vaccination in adults with asthma: Effect on clinical state, airway reactivity, and antibody response. Superior relative effcacy of live attenuated infuenza vaccine com pared with inactivated infuenza vaccine in young children with recurrent respiratory tract infections. Acute transverse myelitis after infuenza vaccination: Magnetic resonance imaging fndings. Safety data on meningococcal poly saccharide vaccine from the Vaccine Adverse Event Reporting System. Excess pneumonia and infuenza associated hospitalization during in fuenza epidemics in the United States, 1970-78. Cuta neous manifestations due to vaccines; prospective study in Lorraine (France) [in French]. Live attenuated versus inactivated infuenza vaccine in infants and young children. Safety, effcacy, and effectiveness of live, attenuated, cold-adapted infuenza vaccine in an indicated population aged 5-49 years. Safety of cold-adapted live attenuated infuenza vaccine in a large cohort of children and adolescents. Miller Fisher syndrome, internal and external ophthalmoplegia after fu vaccination [in Spanish]. Guillain-Barre syndrome following trivalent infuenza vac cine in an elderly patient. Polyneuritis cranialis, brain-stem encephalitis and myelitis following infuenza [in German]. Evaluation of Guillain-Barre syndrome among recipients of infuenza vaccine in 2000 and 2001. Immunization of patients with rheumatoid arthritis against infuenza: A study of vaccine safety and immunogenicity. Evaluation of clinical and immunological effects of inactivated infuenza vaccine in chil dren with asthma. Bronchial responsiveness and leucocyte reactivity after infuenza vaccine in asthmatic patients. The clinical spectrum of the oculo respiratory syndrome after infuenza vaccination. Recurrence risk of oculorespiratory syndrome after infuenza vaccination: Ran domized controlled trial of previously affected persons. Oculo-respiratory syndrome after infuenza vaccination: Trends over four infuenza seasons. Infuenza vaccine administration in patients with sys temic lupus erythematosus and rheumatoid arthritis: Safety and immunogenicity. A case of infuenza vac cination induced Guillain-Barre syndrome with normal cerebrospinal fuid protein and improvement on treatment with corticosteroids. The effect of infiximab and tim ing of vaccination on the humoral response to infuenza vaccination in patients with rheumatoid arthritis and ankylosing spondylitis. Safe administration of an inactivated virosomal adjuvanted infuenza vaccine in asthmatic children with egg allergy. Comparison of the effcacy and safety of live attenuated cold-adapted infuenza vaccine, trivalent, with trivalent inactivated infuenza virus vaccine in children and adolescents with asthma. Safety of the trivalent inactivated infuenza vaccine among children: A population-based study. Ophthalmological and biological features of the oculorespiratory syndrome after infuenza vaccination. Leukocytoclastic vasculitis post-vaccination against infuenza: A report of a case and bibliographical review [in Spanish]. Acute disseminated encephalomyelitis secondary to infuenza vaccination [in Span ish]. The signifcance of vaccination in the pathogenesis of systemic vasculitis [in Polish]. The safety of trivalent infuenza vaccine among healthy children 6 to 24 months of age. Near real-time surveillance for infuenza vaccine safety: Proof-of-concept in the vaccine safety datalink project.

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