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Jeffrey A Brinker, M.D.

Jeffrey A Brinker, M.D.

  • Professor of Medicine
  • Joint Appointment in Radiology and Radiological Science

https://www.hopkinsmedicine.org/profiles/results/directory/profile/0001297/jeffrey-brinker

A test run simulating the standard treatment procedure is performed and also includes check of automatic positioning system accuracy test generic cipro 250 mg on line bacteria 1000x magnification. There are other monthly and annual checks discount cipro 1000mg visa oral antibiotics for acne rosacea, as well as preventive maintenance of the Leksell Gamma Knife best purchase for cipro virus removal software. The test run includes a sector positioning check verifying proper function of automatic collimator set up. The patient docking device function is tested together with overall system accuracy (including patient positioning system and sector positioning) by a diode test tool and focus precision check. Application of the stereotactic frame For Gamma Knife radiosurgery, appropriate stereotactic frame placement is an initial critical part of the procedure. Prior to frame placement, the radiosurgery team should review the preoperative images and discuss optimal frame placement strategy. An effort should be made to keep the lesion as close to the center of the frame as possible. The possibility of collision by the frame base ring, the posts/pins assembly, or the patients head with the collimator helmet during treatment should also be considered prior to the frame application. The frame is shifted lower or higher on the head, to the left or right, or anteriorly or posteriorly, using the ear bars attached to the sides of the base ring. The anterior posts are positioned low along the supraorbital region to avoid collision of frontal post/pin assembly with the collimator helmet. For radiosurgery planning, a higher gamma angle (1200-1400) is used, if a collision is detected at the default angle of 900. While shifting frame laterally, it is important to make sure that there is enough space on the contralateral side to allow positioning of the fiducial box on the base ring of the frame. If the fiducial box does not fit on to the frame due to excessive shifting of the frame, the frame will have to be repositioned. Frame adaptor and Frame cap fitting check the frame adaptor (which attaches the frame to the table) is checked for fit. If the frame is shifted too anteriorly and the back of head ring is too close to the neck adaptor may not fit and consequently treatment can not be carried out. Tight fitting of the adaptor may cause neck discomfort to patient especially during a long treatment. The frame cap check provides information about geometry of all stereotactic frame parts including posts and screws and also information about patient head geometry to the treatment planning system. This information is needed for the prediction of potential collisions or close contact with the gamma knife unit collimator system. If frame cap does not fit then the exact post and screw measurements must be given to the treatment planning system. At our institution high-resolution, a gadolinium enhanced 3-D localizer (T2* images) image sequence is used first to localize the tumor in axial, sagittal, and coronal images. Pituitary lesions are particularly difficult to image especially if there has been prior surgery. A half dose of paramagnetic contrast is usually given to image pituitary adenomas. For thalamotomy planning, an additional fast inversion recovery sequence is performed to differentiate thalamus from the internal capsule. Brain metastases patients receive a double dose of contrast agent and the entire brain is imaged by 2 mm slices to identify all of the lesions. The orthogonal images (instead of oblique or rotated) are preferred but are not necessary. Before removing the angiography catheter the images should be reviewed to make sure that all the fiducials are seen on the images. Digital subtraction techniques, despite a potential radial distortion error, have proven satisfactory spatial accuracy. Determination of Target Volume(s) Target determination is an important step in order to make a conformal plan. Although experienced surgeons can create conformal dose plans without outlining the target, the target outline allows for a more quantitative assessment of the plan. For new centers especially where physicists assume the initial responsibility for planning, target definition and outlining by the surgeon or oncologist becomes an important step. By defining the target volume and volumes of critical structures better evaluation and quantification of the treatment plan can be done. Various parameters such as dose volume histograms for the target volume and critical structures plus conformity indexes can be obtained. Techniques of Conformal Dose Planning In the process of treatment planning, several strategies can be used. Beginners can also use the inverse dose planning algorithm (WizardO) to create a plan and then optimize it manually. Since only 4, 8 and 16 mm collimators are available only combination of these three different collimators can be used to cover the entire target volume. This automatic procedure will provide solutions to block selected sectors to protect volumes defined as critical structures. The treatment planning system then automatically calculates which sectors should be blocked for each individual shots. One should be aware that each blocking will significantly increase total exposure time. The third approach is to use single isocenters composed of different beam diameters or blocked sectors. Any pattern of sectors including 4, 8, 16 mm collimators and blocks can be generated.

The term refers only to the position of the great vessels that is found in association with ventricular septal defects purchase cipro 500 mg alternative for antibiotics for sinus infection, tetralogy of Fallot discount 750mg cipro antibiotics and weed, transposition buy cipro 750 mg lowest price antibiotics for dogs clavamox, univentricular hearts. Prevalence Double-outlet right ventricle is found in less than 1 per 10,000 births. The main echocardiographic features include (a) alignment of the two vessels totally or predominantly from the right ventricle and (b) presence in most cases of bilateral coni (subaortic and subpulmonary). The single arterial trunk is larger than the normal aortic root and is predominantly connected with the right ventricle in about 40% of cases, with the left ventricle in 20%, and is equally shared in 40%. A malalignment ventricular septal defect, usually wide, is an essential part of the malformation. In type 1, the pulmonary arteries arise from the truncus within a short distance from the valve, as a main pulmonary trunk, which then bifurcates. In type 3, only one pulmonary artery (usually the right) originates from the truncus, while the other is supplied by a systemic collateral vessel from the descending aorta. Similar to tetralogy of Fallot, and unlike the other conotruncal malformations, truncus is frequently (about 30%) associated with extracardiac malformations. Diagnosis Truncus arteriosus can be reliably detected with fetal echocardiography. The main diagnostic criteria are: (a) a single semilunar valve overrides the ventricular septal defect (b) there is direct continuity between one or two pulmonary arteries and the single arterial trunk. A peculiar problem found in prenatal echocardiography is the demonstration of the absence of pulmonary outflow tract and the concomitant failure to image the pulmonary arteries. In this situations a differentiation between truncus and pulmonary atresia with ventricular septal defect may be impossible. Prognosis Similar to the other conotruncal anomalies truncus arteriosus is not associated with alteration of fetal hemodynamics. These patients have usually unobstructed pulmonary blood flow and show signs of progressive congestive heart failure with the postnatal fall in pulmonary resistance. Surgical repair (usually before the sixth month of life) involves closure of the ventricular septal defect and creation of a conduit connection between the right ventricle and the pulmonary arteries. Survival from surgery is about 90% but the patients require repeated surgery for replacement of the conduit. Other terms commonly used include left or right isomerism, asplenia and polysplenia. Because of left atrial isomerism (thus absence of right atrium which is the normal location for the pacemaker) and abnormal atrioventricular junctions, atrioventricular blocks are very common. Cardiosplenic syndromes are typically associated with abnormal situs, that is abnormal disposition of abdominal and/or thoracic organs. Prevalence Cardiosplenic syndromes, which represent about 2% of all congenital heart defects, are found in about 1 in 10,000 births. Multiple small spleens (usually too small to be detected by antenatal ultrasound) are found posterior to the stomach. Cardiac anomalies are almost invariably present, including anomalous pulmonary venous return, atrioventricular canal, and obstructive lesions of the aortic valve. One typical and peculiar finding is the interruption of the inferior vena cava, with the lower portion of the body drained by the azygos vein. Evaluation of the disposition of the abdominal organs is of special value for the sonographic diagnosis of fetal cardiosplenic syndromes. In normal fetuses, a transverse section of the abdomen demonstrates the aorta on the left side and the inferior vena cava on the right; the stomach is to left and the portal sinus of the liver bends to the right, towards the gallbladder. In polysplenia, a typical finding is interruption of the inferior vena cava with azygous continuation (there is failure to visualize the inferior vena cava and a large venous vessel, the azygos vein, runs to the left and close to the spine and ascends into the upper thorax). Symmetry of the liver can be sonographically recognized in utero by the abnormal course of the portal circulation that does not display a clearly defined portal sinus bending to the right. The heterogeneous cardiac anomalies found in association with polysplenia are usually easily seen, but a detailed diagnosis often poses a challenge; in particular, assessment of connection between the pulmonary veins and the atrium (an element that has a major prognostic influence) can be extremely difficult. Associated anomalies include absence of the gallbladder, malrotation of the guts, duodenal atresia and hydrops. As in polysplenia, evaluation of the disposition of the abdominal organs is a major clue to the diagnosis. The spleen cannot be seen and the stomach is found in close contact with the thoracic wall. Cardiac malformations are severe, with a tendency towards a single structure replacing normal paired structures: single atrium, single atrioventricular valve, single ventricle and single great vessel, and are usually easily demonstrated. Diagnosis Cardiosplenic syndromes may be inferred by the abnormal disposition of the abdominal organs. Prognosis the outcome depends on the amount of cardiac anomalies, but it tends to be poor. Atrioventricular insufficiency and severe fetal bradycardia due to atrioventricular block may lead to intrauterine heart failure. Etiology Histological studies have shown these foci to be due to mineralization within a papillary muscle. In about 95% of cases they are located in the left ventricle and in 5% in the right ventricle; in 98% they are unilateral and 2% bilateral. Prognosis Echogenic foci are usually of no pathological significance and in more than 90% of cases they resolve by the third trimester or during pregnancy. However they are sometimes associated with cardiac defects and chromosomal abnormalities. For isolated hyperechogenic foci the risk for trisomy 21 may be three-times the background maternal age and gestation related risk. The diagnosis is made by passing an M-mode cursor through one atrium and one ventricle. Premature atrial contractions are spaced closer to the previous contraction than normally and may be transmitted to the ventricle or blocked.

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Following an anti inflammatory discount 750 mg cipro with visa antimicrobial bandages, low glycemic diet can keep your blood sugar stable buy 750 mg cipro free shipping infection of the cervix, improve insulin sensitivity buy discount cipro 750mg on-line bacteria that causes pink eye, and reduce phlegm. Keep your blood sugar stable with a daily schedule of meals and snacks every three to five hours that includes some protein and good fats (for example some nuts/nut butter, seeds/seed butter, hardboiled egg, hummus dip). Protein foods take up to 5 hours to digest while carbohydrate foods digest within 30 minutes. Eat at least three daily servings of fruits like berries,which have a lower glycemic impact. Pay careful attention to portion sizes in order to moderate glucose load and minimize insulin resistance 9. Add one or two Tbsp of cinnamon on cereal each morning to help decrease insulin resistance. Include prebiotic and probiotic foods which promote the growth of beneficial bacteria in the intestinal tract. Prebiotics are found in whole grains, onions, bananas, garlic, honey, leeks, artichokes and some fortified foods. Probiotic foods are found in fermented foods (sauerkraut, live culture yogurt, kim chi, miso). In addition get your heart rate up with at least 30 minutes of vigorous exercise every day. Studies have shown that exercise can reverse diabetes and improve insulin sensitivity as well as help with weight control. Just losing five to ten percent of your body weight, if you are overweight, can restore your menstrual periods and reduce distressing symptoms like facial hair and acne. Some promising studies have shown Chinese herbs to be more effective than Western medicine in stimulating ovulation. You may notice, if you have very long cycles, that ovulation comes earlier in the cycle indicating healthier egg production. You will also see that your quality of skin improves and excess hair will diminish. Male Infertility According to Chinese medicine, reproductive health is the result of your body being in proper balance. Stress, poor lifestyle, inadequate diet and other factors can disturb natural balance. A healthy diet and lifestyle can increase sperm production, increase the percentage of healthy sperm, and improve sperm movement. Research shows that poor eating habits and regular consumption of alcohol, for instance, can lower the quality and quantity of sperm, making conception more difficult. The following diet and lifestyle habits can help with male infertility: Losing excess weight – weight loss can increase testosterone, energy and vitality. Several studies show that even short-term zinc deficiencies can reduce semen volume and testosterone levels. The addition of essential fatty acids and Coenzyme Q10 will help with energy production, blood flow and control inflammation that can interfere with sperm motility. Regardless of the source of infertility, it is important for both partners to support each other in the fertility process. The fertility diet is a healthy diet that supports energy, vitality, longevity, health promotion and disease prevention. It makes sense to follow a well balanced fertility diet to provide optimal conditions for a complete pregnancy. A good quality multivitamin mineral supplement that contains selenium as well as folate is recommended as some research has shown a link between selenium deficiency and miscarriage. Food poisoning masked as flu symptoms and can have serious consequences, including causing miscarriage during the first trimester of pregnancy. Listeria monocytogenes can be found in a variety of dairy products, leafy vegetables, fish and meat products. It can survive cold temperatures and sometimes grows on foods stored in the refrigerator. Toxoplasma is a single-celled parasite transmitted by the consumption of contaminated raw meat, or other raw foods including fruits and vegetables. Many food-borne contaminants do not change the appearance, smell or taste of food. To avoid food-borne illnesses, follow proper food handling practices in the home: Wash hands frequently but especially before preparing and eating food. During pregnancy avoid these foods because of possible bacterial contamination that could cause miscarriage: soft cheeses, such as brie, Camembert and blue veined cheeses deli meats, hot dogs and pates previously cooked seafood and smoked fish raw fish or meat and poultry that is undercooked raw or runny eggs or foods that contain raw eggs (Caesar salad and beverages such as eggnog) unpasteurized dairy or juice products. Overweight Women who have too much stored energy often have difficulty conceiving for other reasons, many of which affect ovulation. These include insensitivity to the hormone insulin, an excess of male sex hormones and overproduction of leptin, a hormone that helps the body keep tabs on body fat. Eat a nutrient rich whole foods diet that is balanced in protein, fat and carbohydrates. Exercise most days of the week, getting your heart rate in the training zone for at least 30 minutes. Mindfulness based stress reduction is an excellent tool for managing stress and has proven to be helpful in managing unbalanced eating behaviours; depression and other stress related concerns. Hunger Satisfaction Level E – the stomach is uncomfortably empty and is a deviation from the self-referral path of comfort – try to eat before getting to this level. Level 0 – 1 – As digestion takes place, there is no remnant of food in your stomach from the previous meal – your stomach seems empty and you feel hunger. Level 2 – 4 this range describes how you feel as you are comfortably continuing to eat and food is being comfortably digested. Underweight Womens health practitioners have known for ages that body fat and energy stores affect reproduction.

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Dietary Boron Modifies the Effects of Vitamin D Nutriture on Energy Metabolism and Bone Morphology in the Chick buy discount cipro 750mg line antibiotic lupin. Dietary Reference Intakes: the Essential Guide to Nutrient Requirements purchase cipro uk bacteria 7th grade science. Effects of vanadyl sulfate on carbohydrate and lipid metabolism in patients with non-insulin-dependent diabetes mellitus buy cipro 1000 mg cheap viruswin32virutce. Pathologic changes in rats and dogs from two-year feeding of sodium arsenite or sodium arsenate. Biochemical and morphological changes associated with long bone abnormalities in silicon deficiency. Cardiovascular system and kidney as specific targets of chronic exposure to vanadate in the rat: Functional and morphological findings. Studies in human lactation 3: Molybdenum and nickel in human milk during the first month of lactation. Arsenic carcinogenesis in animals and in humans: Mecha nistic, experimental, and epidemiological evidence. Cancer potential in liver, lung, blad der and kidney due to ingested inorganic arsenic in drinking water. Fulmi nant malignant arrythmia and multiorgan failure in acute arsenic poisoning. Oral vanadyl sulfate improves hepatic and peripheral insulin sensitivity in pa tients with non-insulin-dependent diabetes mellitus. Inorganic boron health effects in humans: An aid to risk assessment and clinical judgment. Dietary Reference Intakes: the Essential Guide to Nutrient Requirements. Survey of lead, cadmium, cobalt and nickel in infant formulas and evaporated milks and estimation of dietary intakes of the elements by infants 0–12 months old. Survey of lead, cadmium, fluoride, nickel, and cobalt in food composites and estimation of dietary intakes of these elements by Canadians in 1986–1988. Survey of arsenic in total diet food composites and estimation of the dietary intake of arsenic by Canadian adults and children. One-year treatment of non-diabetic and streptozotocin diabetic rats with vanadyl sulphate did not alter blood pressure or haemato logical indices. Further characterization of the posttranslational modifications of core histones in response to heat and arsenite stress in Drosophila. Toxicity and carcinogenicity studies of boric acid in male and female B6C3F1 mice. Effects of vanadium on reproduction, gestation, parturition and lactation in rats upon oral adminis tration. Oral vanadium administration to streptozotocin-diabetic rats has marked negative side-effects which are independent of the form of vanadium used. Boron tolerable intake: Re-evaluation of toxicokinetics for data-derived uncertainty factors. Special Report on Ingested Inorganic Arsenic: Skin Cancer; Nutritional Essentiality. Dietary Reference Intakes: the Essential Guide to Nutrient Requirements. National primary drinking water regulations; Arsenic and clarifications to compliance and new source contaminants monitoring; Proposed rule. Oral vanadyl sulphate does not affect blood cells, viscosity or biochemistry in humans. Adverse reproductive and developmental effects in Xenopus from insufficient boron. Chronic feeding of a low boron diet adversely affects reproduction and development in Xenopus laevis. The toxicity of orally ingested arsenic, selenium, tellurium, vanadium and molybdenum. Pesticides, selected elements, and other chemicals in adult total diet samples, October 1978–Sep tember 1979. Dietary Reference Intakes: the Essential Guide to Nutrient Requirements. Determination of seven trace elements in human milk, powdered cows milk and infant foods by neutron activation analysis. Effect of vanadate on elevated blood glucose and depressed cardiac performance of diabetic rats. Human studies do not support the methylation threshold hypothesis for the toxicity of inorganic arsenic. Deliberations and evaluations of the approaches, endpoints and paradigms for boron, chromium and fluoride dietary recom mendations. Concentration of boron and other ele ments in human foods and personal-care products. Dietary Reference Intakes: the Essential Guide to Nutrient Requirements. Gastro-intestinal absorption and in vitro release of boric acid from water-emulsifying ointments. Effect of fiber from fruits and vegetables on metabolic responses of human subjects. Common cis-acting region responsible for transcrip tional regulation of Bradyrhizobium japonicum hydrogenase by nickel, oxy gen, and hydrogen.

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The child in Home B also had difficulty breathing buy cipro paypal virus yontooc, and again had to be taken out of school effective cipro 750 mg antibiotics metronidazole. Doctors of the families in both homes warned them to leave their homes for at least 30 days or suffer more severe health consequences order cipro cheap antibiotics questions. After one month of being away, the phenol levels as well as the symptoms of the children in Home B decreased, while the owner of Home B, who returns to the home for a few hours each day, has increased phenol levels and worsening of symptoms. One of the owners in Home A, who works at home, has experienced worsening of symptoms. Animals live among us and are exposed to the same environmental influences; however, they tend to suffer more direct exposure and have shorter life and reproductive cycles. Case 2 In this case, a beef cattle farmer had a herd of 96 cattle (Angus Limousine cross) that was divided among three pastures. The farm is located in an area of intensive gas drilling, with two active shallow vertical gas wells on the farmers property and approximately 190 active gas wells within five miles of the property; of these, approximately 11 are shale gas wells and approximately 26 are deep vertical gas wells. In one pasture, 60 cows (a mixed herd, mostly 5 to 10-year-old bred cows) had access to a creek as a source of water. In a second pasture, 20 cows (bred yearlings) obtained water from hillside runoff, and in a third pasture, 14 feeder calves (8 to 14 months old) and two bulls had access to a pond. Over a three-month period, 21 head from the creek-side pasture died (17 adult bred cows and 4 calves). Despite symptomatic treatment, deaths occurred 1 to 3 days after the cows went down and were unable to rise. On rendering, 16 of the 17 adults were found to have dead fetuses, nearly doubling this farmers losses. Of the 39 cows on the creek-side pasture that survived, 16 failed to breed and several cows produced stillborn calves with white and blue eyes. The health of the cattle on the other two pastures was unaffected; on the second pasture, only one cow failed to breed. Historically, the health of the herd was good, the farmer reporting average losses of 1-2 cows a year in his herd of nearly 100 cattle. That is, the cattle that were kept along the creek suffered severe problems while the cattle in pastures at a higher elevation and away from the creek experienced no morbidity or mortality. As discussed below, the contamination of the creek may have been caused by illegal dumping of wastewater. However, they still may have entered our food chain as well as that of our pets: rendering plants produce feed for many non-ruminants including chickens, pigs, cats, dogs and horses, so it is possible that chickens, raised for egg production or meat, and pigs were fed the flesh from these cattle. Case 3 this case concerns farmers that have raised beef cattle (Herford Simmental cross) for the past 21 years. Before drilling operations began the farmers lost one or two animals out of a closed herd of 33 (yearlings, heifers, mature cows, two bulls) every few years to illness or accident. There is one active shale gas well on the farmers 530-acre property, and approximately six active shale gas wells within two miles of their property. The well pad is 75 feet from their barn at higher elevation, and slopes directly down to the door. Soon after hydraulic fracturing operations concluded, the farmers noticed that on the far bank of the wastewater impoundment, two dark spots could be seen adjacent to a 20-acre cow pasture. According to the farmers, these two spots were a concern as they grew in size from day to day; approximately one month after first observing these spots, the farmers found ankle-deep water in one-third of an acre of the pasture with the wet area extending another one-quarter of an acre into the pasture; the pasture grass in these areas appeared to be burned. Fearing their herd drank the wastewater, they voluntarily quarantined their farm and notified the state environmental regulatory agency. According to the farmers, drilling company workers informed them that the liners of both the wastewater impoundment and the drilling muds pit had two-foot tears, and that the tear in the liner of the wastewater impoundment had caused the leak into the cow pasture. Four notices of violations were issued to the drilling company by the state environmental regulatory agency: failure to notify the agency, improperly lined impoundment (pressure testing of liner revealed a failed patch), pollution of a spring and farm pond due to leakage of the impoundment, and mismanagement of residual waste (wastewater leaked from the impoundment onto the ground and surfaced in an adjacent pasture). Testing of the wastewater in the impoundment indicated the presence of calcium, iron, magnesium, manganese, potassium, sodium, strontium, fluoride, chloride, sulfate, and bromide; there was no reported testing for any organic compounds. Strontium was of most concern: it can be toxic to both animals and people because it replaces calcium in bone, especially in the young, and because it may take years to be eliminated from the body [43]. The state environ mental regulatory agency placed a quarantine on the herd such that mature cows would be held from slaughter for six months, yearlings would be held for nine months, calves exposed in utero would be held for eight months, and growing calves would be held for two years. Six of the exposed cows eventually went on to slaughter, and, according to the farmers, there was no testing before or after slaughter. Pre-drilling tests were not done on any of the cattles sources of water; post-drilling tests were done and revealed no significant findings. The liners from both the wastewater impoundment and drilling-muds pit were removed, the affected soil removed, and areas remediated; sulfate concentrations remained at high levels in the cow pasture despite remediation. During the spring of the first calving season following the leakage of wastewater into their cow pasture, the farmers lost two calves: one calf was aborted late-term, and the other calf lived for approximately seven days before dying [44]; both calves were exposed in utero to the wastewater. In the second calving season post-drilling, the farmers lost 11 out of 17 calves: seven were stillborn, three died a few months after birth and one was born alive but severely ill; the dams of all the calves had previously been exposed to the wastewater. The severely ill calf and a stillborn calf were sent for necropsy: the ill calf was diagnosed with E. According to the farmers, they were not informed of the chemicals used during either drilling or hydraulic fracturing operations. Testing of the water well and cattles sources of water excluded organic compounds except for a pasture spring; the wastewater analysis also excluded organic compounds. No toxicology tests were done on live cattle, and the tests at necropsy omitted volatile organic compounds, endocrine disruptors, and many minerals present in the wastewater. The cattles sources of water were tested only after the farmers lost many calves. Soil tests were not done in the area affected by the leakage of the drilling-muds pit.

References:

  • https://pubs.usgs.gov/circ/1422/circ1422_3-environment.pdf
  • https://ibis.sco.idaho.gov/pubtrans/workforce/Workforce%20by%20Name%20Summary-en-us.pdf
  • http://www.leonchaitow.com/wp-content/uploads/2016/12/Naturopathic-Physical-Medicine.pdf
  • https://scholarworks.umass.edu/dissertations/
  • https://www.researchgate.net/publication/287213672_Changing_the_Face_of_Veterinary_Medicine_Research_and_Clinical_Developments_at_AAVMC_Institutions
 
 
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